CMR T1 measurements of myocardium and blood before and after contrast allow quantification of the ECV. This study aimed to test the characteristics of the myocardial extracellular volume fraction (ECV) derived from pre- and post-contrast T1 measurements among healthy volunteers.
Conclusions In healthy volunteers, the myocardial ECV ranges from 0.23 to 0.33, has acceptable test characteristics, and is associated with age, left atrial volume, and left ventricular mass. In mice, the ECV also increases with age and strongly correlates with the extent of myocardial fibrosis.
Source: Tomas G. Neilan, MD; Otavio R. Coelho-Filho, MD, MPH; Ravi V. Shah, MD; Siddique A. Abbasi, MD; Bobak Heydari, MD; Eri Watanabe, MD, PhD; Yucheng Chen, MD; Damien Mandry, MD; Francois Pierre-Mongeon; Ron Blankstein, MD; Raymond Y. Kwong, MD, MPH; Michael Jerosch-Herold, PhD. Myocardial Extracellular Volume Fraction From T1 Measurements in Healthy Volunteers and Mice. J Am Coll Cardiol Img. 2013;6(6):672-683